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recombinant human dpp 4  (Sino Biological)


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    Sino Biological recombinant human dpp 4
    Recombinant Human Dpp 4, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+human+dpp+4/Human+DPP4+%2F+DPPIV+%2F+CD26+Protein/pm40484085-45-28-35
    Average 93 stars, based on 7 article reviews
    recombinant human dpp 4 - by Bioz Stars, 2026-10
    93/100 stars

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    Related Articles

    Recombinant:

    Article Title: Comprehending the mechanism of catechins against α-glucosidase by multispectral data and their antidiabetic effects in vivo.
    Article Snippet: Diabetes mellitus (DM) is a common metabolic disorder characterized by the elevated blood glucose levels.. Catechins comprising four isomers, (+)-catechin [(+)CT], (− )-catechin [(− )CT], (+)-epicatechin [(+)ECT] and (− )-epicatechin [(− )ECT], are a family of flavanols widespread in natural sources.. In this study, four catechins were extensively evaluated against diabetes-related enzymes, of which (+)CT (IC50 = 63.5 μM) and (+)ECT (IC50 = 73.8 μM) were revealed with significant activity against α-glucosidase, about 6.1 and 5.2 times higher than the positive control, acarbose (IC50 = 388.0 μM).



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    Neprilysin deficiency reduces <t>DPP-4</t> activity and enhances active GLP-1 levels in high-fat fed mice. (a) Plasma neprilysin activity levels in Nep+/+ mice over 16 weeks of low- or high-fat feeding. White squares, Nep+/+/low-fat diet; black squares, Nep+/+/high-fat diet. (b, c) Plasma (b) DPP-4 activity and (c) active GLP-1 levels in Nep+/+ and Nep−/− mice fed a low- or high-fat diet for 16 weeks. Data are means ± SEM; n=9–17. *p<0.05 vs Nep+/+, †p<0.05 vs the low-fat diet. White bars, low-fat diet; black bars, high-fat diet. MNA, methoxy-2-naphthylamine
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    Image Search Results


    Neprilysin deficiency reduces DPP-4 activity and enhances active GLP-1 levels in high-fat fed mice. (a) Plasma neprilysin activity levels in Nep+/+ mice over 16 weeks of low- or high-fat feeding. White squares, Nep+/+/low-fat diet; black squares, Nep+/+/high-fat diet. (b, c) Plasma (b) DPP-4 activity and (c) active GLP-1 levels in Nep+/+ and Nep−/− mice fed a low- or high-fat diet for 16 weeks. Data are means ± SEM; n=9–17. *p<0.05 vs Nep+/+, †p<0.05 vs the low-fat diet. White bars, low-fat diet; black bars, high-fat diet. MNA, methoxy-2-naphthylamine

    Journal: Diabetologia

    Article Title: Improved glycaemia in high-fat fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels

    doi: 10.1007/s00125-016-4172-4

    Figure Lengend Snippet: Neprilysin deficiency reduces DPP-4 activity and enhances active GLP-1 levels in high-fat fed mice. (a) Plasma neprilysin activity levels in Nep+/+ mice over 16 weeks of low- or high-fat feeding. White squares, Nep+/+/low-fat diet; black squares, Nep+/+/high-fat diet. (b, c) Plasma (b) DPP-4 activity and (c) active GLP-1 levels in Nep+/+ and Nep−/− mice fed a low- or high-fat diet for 16 weeks. Data are means ± SEM; n=9–17. *p<0.05 vs Nep+/+, †p<0.05 vs the low-fat diet. White bars, low-fat diet; black bars, high-fat diet. MNA, methoxy-2-naphthylamine

    Article Snippet: Recombinant human DPP-4 (R&D Systems, Minneapolis, MN, USA) was then added at a final concentration of 0.01, 0.05 or 0.1 µmol/l, and incubated for 1 h at 37°C.

    Techniques: Activity Assay

    Ex vivo pharmacological inhibition of neprilysin activity reduces DPP-4 activity in plasma from high fat fed mice. (a) Neprilysin and (b) DPP-4 activity levels in plasma treated ex vivo with dl-thiorphan or vehicle from Nep+/+ mice fed a low- or high-fat diet for 16 weeks. (c) DPP-4 activity following in vitro incubation of recombinant neprilysin and DPP-4 with dl-thiorphan. Neprilysin:DPP-4 molar ratios of 1:5 and 1:10 were tested. Incubation of recombinant neprilysin and DPP-4 with diprotin A served as a positive control. Data are means ± SEM. (a, b) n=5 per group. n=3 per Neprilysin:DPP-4 molar ratio. White bars, low-fat diet; black bars, highfat diet. (c) Black bars, 1:5 Neprilysin:DPP-4 molar ratio; White bars, 1:10 Neprilysin:DPP-4 molar ratio. *p<0.05 vs vehicle, †p<0.05 vs low-fat diet. MNA, methoxy-2-naphthylamine

    Journal: Diabetologia

    Article Title: Improved glycaemia in high-fat fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels

    doi: 10.1007/s00125-016-4172-4

    Figure Lengend Snippet: Ex vivo pharmacological inhibition of neprilysin activity reduces DPP-4 activity in plasma from high fat fed mice. (a) Neprilysin and (b) DPP-4 activity levels in plasma treated ex vivo with dl-thiorphan or vehicle from Nep+/+ mice fed a low- or high-fat diet for 16 weeks. (c) DPP-4 activity following in vitro incubation of recombinant neprilysin and DPP-4 with dl-thiorphan. Neprilysin:DPP-4 molar ratios of 1:5 and 1:10 were tested. Incubation of recombinant neprilysin and DPP-4 with diprotin A served as a positive control. Data are means ± SEM. (a, b) n=5 per group. n=3 per Neprilysin:DPP-4 molar ratio. White bars, low-fat diet; black bars, highfat diet. (c) Black bars, 1:5 Neprilysin:DPP-4 molar ratio; White bars, 1:10 Neprilysin:DPP-4 molar ratio. *p<0.05 vs vehicle, †p<0.05 vs low-fat diet. MNA, methoxy-2-naphthylamine

    Article Snippet: Recombinant human DPP-4 (R&D Systems, Minneapolis, MN, USA) was then added at a final concentration of 0.01, 0.05 or 0.1 µmol/l, and incubated for 1 h at 37°C.

    Techniques: Ex Vivo, Inhibition, Activity Assay, In Vitro, Incubation, Recombinant, Positive Control